Probabilistic inference is fundamentally hard, yet many tasks require optimization on top of inference, which is even harder. We present a new \textit{optimization-via-compilation} strategy to scalably solve a certain class of such problems. In particular, we introduce a new intermediate representation (IR), binary decision diagrams weighted by a novel notion of \textit{branch-and-bound semiring}, that enables a scalable branch-and-bound based optimization procedure. This IR automatically \textit{factorizes} problems through program structure and \textit{prunes} suboptimal values via a straightforward branch-and-bound style algorithm to find optima. Additionally, the IR is naturally amenable to \textit{staged compilation}, allowing the programmer to query for optima mid-compilation to inform further executions of the program. We showcase the effectiveness and flexibility of the IR by implementing two performant languages that both compile to it: DAPPL and PINEAPPL. DAPPL is a functional language that solves maximum expected utility problems with first-class support for rewards, decision making, and conditioning. PINEAPPL is an imperative language that performs exact probabilistic inference with support for nested marginal maximum a posteriori (MMAP) optimization via staging.